Hypothesis Research Programs
Testable predictions across major disease areas, building on decades of foundational research. Each hypothesis is specific, falsifiable, and designed for validation by the scientific community.
Our Approach
Cross-system analysis generates hypotheses by identifying patterns that span traditional research boundaries. But patterns are not proof—they are invitations to investigate.
"We present correlations that suggest testable predictions. Whether these predictions prove correct is a question only rigorous validation can answer."
Every hypothesis here builds on the work of thousands of researchers who established the biological foundations we synthesize. Our contribution is not discovering the underlying biology—it is noticing connections between established findings that may have been overlooked due to specialization.
We explicitly invite scrutiny. If we are wrong, we want to know. Science advances through correction as much as confirmation.
Research Programs
Microbiome & Immunity
Unifying Framework — NEW
The master orchestrator connecting all domains. Hypotheses on butyrate-autoimmunity, immunotherapy response prediction, gut-brain axis, early-life programming, and barrier dysfunction.
Cancer
10 million deaths annually
Hypotheses on oncogene hierarchies, checkpoint inhibitor optimization, cross-cancer drug repurposing, and tissue-agnostic response prediction.
Neurodegeneration
65+ million patients worldwide
Hypotheses on CV-Alzheimer's connections, protein aggregation convergence, anti-amyloid optimization, and ALS drug repurposing.
Cardiovascular Disease
18 million deaths annually
Hypotheses on statin response heterogeneity, inflammation-CV convergence, GLP-1 clustering, and cross-class drug synergy.
Diabetes
537 million patients, 6.7M deaths/year
Hypotheses on T1D-autoimmune prevention, GLP-1 cross-disease effects, gene-drug matching, and CV-glycemic integration.
Mental Health
1 billion+ affected, 700K suicides/year
Hypotheses on depression-inflammation axis, SSRI clustering, 22q-schizophrenia pathways, and novel treatment mechanisms.
Autoimmune Disease
300-500 million affected globally
Hypotheses on cross-biologic response prediction, PTPN22 pharmacogenomics, JAK inhibitor optimization, and sequential therapy.
22q11.2 Deletion Syndrome
Flagship Research Program
Our most developed research area. Full literature review, validated hypotheses, clinical protocols, and publication-ready manuscripts.
Combined Potential Impact
If even a fraction of these hypotheses prove correct and lead to improved treatments, the impact would be measured in millions of lives.
Our Commitments
- Pre-registration: All hypotheses are specified before validation attempts, ensuring we cannot move goalposts after seeing results.
- Falsifiability: Each hypothesis includes specific predictions that can be tested and potentially disproven.
- Data transparency: We specify what data would be needed to test each hypothesis and actively seek collaborators with access to such data.
- Attribution: We explicitly acknowledge the foundational research on which these syntheses are built.
- No mechanism claims: We identify correlations and patterns, not causal mechanisms. The "why" remains an open question.
These hypotheses are designed to be validated by the broader scientific community. If you have access to relevant data or expertise in any of these areas, we welcome discussion and collaboration.